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Immediately after vaccination with the new coronavirus vaccine, it has been reported that a small number of severe allergic reactions cause anaphylactic shock. The corona vaccine is developed and manufactured using a technique different from that of the conventional vaccine, and it has been clarified that the frequency of anaphylaxis is higher than that of the conventional vaccine in Europe and the United States where inoculation has started in advance. .. However, it is said that it can be recovered with appropriate measures and it is unlikely that it will develop into a serious situation.

Anaphylaxis is one of the allergic reactions that can occur as a side reaction after medication or vaccination, as well as food. The symptoms vary, with skin symptoms such as urticaria, redness, and itching, followed by respiratory symptoms such as swelling, coughing, and breathlessness, and mucosal symptoms such as itching and edema of the eyes and swelling of the lips. Then there are gastrointestinal symptoms such as abdominal pain, diarrhea and vomiting, and respiratory symptoms such as decreased blood pressure. When allergic symptoms occur in two or more organs at the same time, it is called anaphylaxis. For example, rash and suffocation, suffocation and abdominal pain, abdominal pain and runny nose. When such anaphylaxis causes a decrease in consciousness level or weakness due to a decrease in blood pressure, it is called anaphylaxis shock, and it may be fatal if not properly treated.

Anaphylaxis that occurs after drug administration or vaccination is often said to develop within 30 minutes immediately after administration. Anaphylaxis caused by the new coronavirus vaccine often develops 15 to 30 minutes after administration. It has been reported that anaphylaxis rarely occurs with existing vaccines, and that it is more frequent with the new coronavirus vaccine.

The international standard (definition) for anaphylaxis is the "Brighton classification". It classifies the severity of symptoms, blood pressure, pulse rate, and other vital signs. It is divided into levels 1 to 5, (1) 1 to 3 are anaphylaxis, (2) 4 is not sufficient information and cannot be judged to meet the case definition, and (3) 5 is not anaphylaxis. Symptoms to meet the criteria consist of skin / mucosal symptoms and cardiovascular, respiratory and digestive symptoms.

In Japan, anaphylaxis was judged to be anaphylaxis by international standards in 94 cases out of about 2.51 million inoculations (Pfizer's mRNA vaccine, Kominati intramuscular injection) from February 17 to April 22. When converted to 1 million inoculations, it will be 37 cases. The incidence is decreasing due to the increase in the number of inoculations.

From Document 1-5 of the 53rd Health Science Council Vaccination and Vaccine Subcommittee Adverse Reaction Review Subcommittee

The breakdown is 33 cases with a history of allergies and 58 cases without a history. By gender, there are 9 males and 85 females, which is characteristic of women in their 30s and 50s. It is speculated that polyethylene glycol (PEG), which is used in cosmetics, is included in Pfizer vaccines as the reason why it is common among women. In other words, women who use a lot of cosmetics may already be sensitized to PEG. It is also believed that the high proportion of female nurses in the proportion of healthcare workers who have already been vaccinated is also a factor.

If anaphylactic shock occurs after vaccination, intramuscular injection of adrenaline, which is the first-line treatment, is the remedy, followed by inhalation of bronchodilators, antihistamines, instillation of steroids, and oral administration. I will do it. In many cases, it will recover with appropriate measures, and it is rare that it will develop into a serious situation.